Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell population expansion

Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell population expansion

Abstract In response to infection or vaccination, lymph nodes must select antigen-reactive B-cells while eliminating auto-reactive B-cells. B-cells are instructed via B-cell receptor (BCR), which binds antigen, and CD40 receptor by antigen-recognizing T-cells. How BCR and CD40 signaling are integrat...

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Bibliographic Details
Main Authors: Helen Huang, Haripriya Vaidehi Narayanan, Mark Yankai Xiang, Vaibhava Kesarwani, Alexander Hoffmann
Format: Article
Language:English
Published: Springer Nature 2025-06-01
Series:Molecular Systems Biology
Subjects:
B-cell Selection
B-cell Signaling
NFκB
Mathematical Modeling
Systems Immunology
Online Access:https://doi.org/10.1038/s44320-025-00124-2
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https://doi.org/10.1038/s44320-025-00124-2

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