TNFR2 blockade promotes antitumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion

TNFR2 blockade promotes antitumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion

Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, highly resistant to standard chemotherapy and immunotherapy. Regulatory T cells (Tregs) expressing tumor necrosis factor α receptor 2 (TNFR2) contribute to immunosuppression in PDAC. Treg infiltration correlate...

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Main Authors: Eliane Piaggio, Allan Thiolat, Anais Debesset, Caroline Pilon, Benoît Laurent Salomon, José Laurent Cohen, Sylvain Baulande, Sylvain Meunier, Orianne Cuelenaere-Bonizec, Wilfrid Richer, Claire Houppe, Matteo Ponzo, Jeanne Magnan, Jonathan Caron, Pamela Caudana, Jimena Tosello Boari, Nhu Han To, Ilaria Cascone
Format: Article
Language:English
Published: BMJ Publishing Group 2024-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/11/e008898.full
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https://jitc.bmj.com/content/12/11/e008898.full

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