Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex

Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex

The translation initiation complex 4F (eIF4F) is a rate-limiting factor in protein synthesis. Alterations in eIF4F activity are linked to several diseases, including cancer and infectious diseases. To this end, coronaviruses require eIF4F complex activity to produce proteins essential for their life...

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Bibliographic Details
Main Authors: Yongmei Feng, Stefan Grotegut, Predrag Jovanovic, Valentina Gandin, Steven H. Olson, Rabi Murad, Anne Beall, Sharon Colayco, Paul De-Jesus, Sumit Chanda, Brian P. English, Robert H. Singer, Michael Jackson, Ivan Topisirovic, Ze’ev A. Ronai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
COVID-19
OC43
SARS-CoV-2
coronavirus
eIF4F
translation initiation complex
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1029093/full
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https://www.frontiersin.org/articles/10.3389/fphar.2022.1029093/full

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