CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells

CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells

To encode continuous sound stimuli, the inner hair cell (IHC) ribbon synapses utilize calcium-binding proteins (CaBPs), which reduce the inactivation of their CaV1.3 calcium channels. Mutations in the CABP2 gene underlie non-syndromic autosomal recessive hearing loss DFNB93. Besides CaBP2, the struc...

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Bibliographic Details
Main Authors: David Oestreicher, Shashank Chepurwar, Kathrin Kusch, Vladan Rankovic, Sangyong Jung, Nicola Strenzke, Tina Pangrsic
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
DFNB93
calcium channel
hearing impairment
ribbon synapse
CACNA1D
Online Access:https://elifesciences.org/articles/93646
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https://elifesciences.org/articles/93646

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