Interferon-induced transmembrane protein 3 (IFITM3) gene polymorphisms in COVID-19 patients in Assiut University Hospitals
Background and aims: Interferon-induced transmembrane protein 3 (IFITM3) plays an important antiviral role in the adaptive and innate immune response, it prevents hemifusion of the viral membrane and host cellular membrane in a broad spectrum of enveloped viruses, e.g. influenza A, ebola, marburg or...
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Zagazig University, Faculty of Medicine
2024-05-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_339065_b99da2ae192bbe788379398ee4b0c0e3.pdf |
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| author | Esraa Abdelaziz Amany Nafeh Ahmed Hasanein Hytham Abdalla Ragaa Rashwan |
| author_facet | Esraa Abdelaziz Amany Nafeh Ahmed Hasanein Hytham Abdalla Ragaa Rashwan |
| author_sort | Esraa Abdelaziz |
| collection | DOAJ |
| description | Background and aims: Interferon-induced transmembrane protein 3 (IFITM3) plays an important antiviral role in the adaptive and innate immune response, it prevents hemifusion of the viral membrane and host cellular membrane in a broad spectrum of enveloped viruses, e.g. influenza A, ebola, marburg or SARS-CoV. This study aimed to evaluate correlation of IFITM3 gene polymorphisms (rs12252) and infection susceptibility, severity and mortality rate of COVID-19 patients. Patients and methods: The IFITM3 SNP (rs12252) polymorphism was genotyped by (RT-PCR) in 100 SARS-CoV-2-negative controls and 100 SARS-CoV-2- positive, who admitted to Chest, Assiut University and other quarantine Hospitals respectively in Assiut city, Egypt. Results: The minor allele frequency (rs12252 (G)) were significantly more frequent in the patients compared to controls after age and sex matching (p-value = 0.011, OR (95% CI) =2.44 (1.20-4.97). This allele (G) was significantly more common among patients who ICU admitted than non-ICU admitted (p -value = 0.001, OR (95% CI) =3.78 (1.64-8.75)). Also, was significantly more frequent in dead patients than cured patients (p -value = 0.005, OR (95% CI) =3.33 (1.37-8.10)). Conclusion: The present study has shown significant association between G (the mutant type) allele variant of IFITM3 rs12252 and COVID-19 infection susceptibility and disease severity and mortality. |
| format | Article |
| id | doaj-art-3f08f28fd7ae4132a08a4e074d4fa349 |
| institution | Kabale University |
| issn | 2682-4132 2682-4140 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj-art-3f08f28fd7ae4132a08a4e074d4fa3492024-12-21T21:02:47ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402024-05-015245146210.21608/mid.2024.258008.1732339065Interferon-induced transmembrane protein 3 (IFITM3) gene polymorphisms in COVID-19 patients in Assiut University HospitalsEsraa Abdelaziz0Amany Nafeh1Ahmed Hasanein2Hytham Abdalla3Ragaa Rashwan4Microbiology and Immunology Department, Faculty of Pharmacy, Assiut University, Assiut- Egypt.Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Chest Diseases, Faculty of Medicine, Al-Azhar University Assiut, Assiut, Egypt.Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, EgyptBackground and aims: Interferon-induced transmembrane protein 3 (IFITM3) plays an important antiviral role in the adaptive and innate immune response, it prevents hemifusion of the viral membrane and host cellular membrane in a broad spectrum of enveloped viruses, e.g. influenza A, ebola, marburg or SARS-CoV. This study aimed to evaluate correlation of IFITM3 gene polymorphisms (rs12252) and infection susceptibility, severity and mortality rate of COVID-19 patients. Patients and methods: The IFITM3 SNP (rs12252) polymorphism was genotyped by (RT-PCR) in 100 SARS-CoV-2-negative controls and 100 SARS-CoV-2- positive, who admitted to Chest, Assiut University and other quarantine Hospitals respectively in Assiut city, Egypt. Results: The minor allele frequency (rs12252 (G)) were significantly more frequent in the patients compared to controls after age and sex matching (p-value = 0.011, OR (95% CI) =2.44 (1.20-4.97). This allele (G) was significantly more common among patients who ICU admitted than non-ICU admitted (p -value = 0.001, OR (95% CI) =3.78 (1.64-8.75)). Also, was significantly more frequent in dead patients than cured patients (p -value = 0.005, OR (95% CI) =3.33 (1.37-8.10)). Conclusion: The present study has shown significant association between G (the mutant type) allele variant of IFITM3 rs12252 and COVID-19 infection susceptibility and disease severity and mortality.https://mid.journals.ekb.eg/article_339065_b99da2ae192bbe788379398ee4b0c0e3.pdfkeywords: sars-cov-2snpgenotypingrs12252rt-pcr |
| spellingShingle | Esraa Abdelaziz Amany Nafeh Ahmed Hasanein Hytham Abdalla Ragaa Rashwan Interferon-induced transmembrane protein 3 (IFITM3) gene polymorphisms in COVID-19 patients in Assiut University Hospitals Microbes and Infectious Diseases keywords: sars-cov-2 snp genotyping rs12252 rt-pcr |
| title | Interferon-induced transmembrane protein 3 (IFITM3) gene polymorphisms in COVID-19 patients in Assiut University Hospitals |
| title_full | Interferon-induced transmembrane protein 3 (IFITM3) gene polymorphisms in COVID-19 patients in Assiut University Hospitals |
| title_fullStr | Interferon-induced transmembrane protein 3 (IFITM3) gene polymorphisms in COVID-19 patients in Assiut University Hospitals |
| title_full_unstemmed | Interferon-induced transmembrane protein 3 (IFITM3) gene polymorphisms in COVID-19 patients in Assiut University Hospitals |
| title_short | Interferon-induced transmembrane protein 3 (IFITM3) gene polymorphisms in COVID-19 patients in Assiut University Hospitals |
| title_sort | interferon induced transmembrane protein 3 ifitm3 gene polymorphisms in covid 19 patients in assiut university hospitals |
| topic | keywords: sars-cov-2 snp genotyping rs12252 rt-pcr |
| url | https://mid.journals.ekb.eg/article_339065_b99da2ae192bbe788379398ee4b0c0e3.pdf |
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