Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults

Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults

Declines in skeletal muscle and cognitive function in older adults have been linked to abnormalities in abdominal subcutaneous adipose tissue (ASAT), yet the underlying molecular mediators remain poorly understood. Here, leveraging ASAT transcriptomics and explant-conditioned media proteomics from p...

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Main Authors: Cheehoon Ahn, Ian Tamburini, James A. Sanford, Mingqi Zhou, Farah Gamie, Reichelle X. Yeo, Carlos H. Viesi, Maria Pino, Katie L. Whytock, Lauren E. Oberlin, Theresa Mau, Joshua N. Adkins, Jamie N. Justice, Ashlee N. Wood, Zana M. Ross, Paul.D. Piehowski, Chelsea M. Hutchinson Bunch, Kirk I. Erickson, Frederico G.S. Toledo, Nancy E. Lane, Peggy M. Cawthon, Anne B. Newman, Stephen B. Kritchevsky, Steven R. Cummings, Bret H. Goodpaster, Erin E. Kershaw, Marcus M. Seldin, Lauren M. Sparks
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Metabolism
Subjects:
Aging
Physical function
Cognitive function
Subcutaneous adipose tissue
Secretome
Tissue crosstalk
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825001206
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