Renoprotective effects of GHRH agonist MR409 is associated with reduced oxidative stress and ferroptosis in diabetic mice

Renoprotective effects of GHRH agonist MR409 is associated with reduced oxidative stress and ferroptosis in diabetic mice

MR409, a synthetic growth hormone-releasing hormone (GHRH) analogue, has demonstrated therapeutic potential in enhancing islet cell transplantation efficacy in diabetes mice and exerts beneficial effects on cardiovascular diseases. The present study investigated the renoprotective effects of MR409 o...

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Bibliographic Details
Main Authors: Yueyang Liu, Rong Fu, Qi Tang, Yaoxia Zhang, Ruiping Cai, Limin Liu, Hui Jia, Junjia Gao, Ming-Sheng Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
growth hormone-release hormone analogue
diabetic nephropathy
oxidative stress
ferroptosis
Klotho
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1617185/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1617185/full

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