Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis

Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis

Abstract Pulmonary fibrosis (PF) is a chronic, progressive lung disease characterized by fibroblast proliferation, extensive extracellular matrix and collagen deposition, accompanied by inflammatory damage, ultimately leading to death due to respiratory failure. Endoplasmic reticulum (ER) stress in...

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Bibliographic Details
Main Authors: Zhiheng Sun, Wanyu He, Huiwen Meng, Zhihua Ji, Junxing Qu, Guoying Yu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Respiratory Research
Subjects:
Pulmonary fibrosis
Lactate
Endoplasmic reticulum stress
Caspase-12
Alveolar epithelial cells
Apoptosis
Online Access:https://doi.org/10.1186/s12931-024-03016-5
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https://doi.org/10.1186/s12931-024-03016-5

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