CHAC1 Mediates Endoplasmic Reticulum Stress‐Dependent Ferroptosis in Calcium Oxalate Kidney Stone Formation

CHAC1 Mediates Endoplasmic Reticulum Stress‐Dependent Ferroptosis in Calcium Oxalate Kidney Stone Formation

Abstract The initiation of calcium oxalate (CaOx) kidney stone formation is highly likely to stem from injury to the renal tubular epithelial cells (RTECs) induced by stimulation from an aberrant urinary environment. CHAC1 plays a critical role in stress response mechanisms by regulating glutathione...

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Bibliographic Details
Main Authors: Caitao Dong, Ziqi He, Wenbiao Liao, Qinhong Jiang, Chao Song, Qianlin Song, Xiaozhe Su, Yunhe Xiong, Yunhan Wang, Lingchao Meng, Sixing Yang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
ATF4
CHAC1
endoplasmic reticulum stress
ferroptosis, kidney stone
Online Access:https://doi.org/10.1002/advs.202403992
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https://doi.org/10.1002/advs.202403992

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