SARS-CoV-2 investigation in cerebrospinal fluid from meningitis patients during the first pandemic wave
SARS-CoV-2 predominantly affects the respiratory system; however, during the first pandemic wave, there was a concern about its neuroinvasive potential due to its ability to replicate in neural cells and the neurological signs widely reported as impaired taste or smell. This study aimed to evaluate...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867025000728 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849340471453679616 |
|---|---|
| author | Maria Cecilia Cergole-Novella Thayná Rosa Bispo Elaine Monteiro Matsuda Daniela Rodrigues Colpas Ivana Barros de Campos |
| author_facet | Maria Cecilia Cergole-Novella Thayná Rosa Bispo Elaine Monteiro Matsuda Daniela Rodrigues Colpas Ivana Barros de Campos |
| author_sort | Maria Cecilia Cergole-Novella |
| collection | DOAJ |
| description | SARS-CoV-2 predominantly affects the respiratory system; however, during the first pandemic wave, there was a concern about its neuroinvasive potential due to its ability to replicate in neural cells and the neurological signs widely reported as impaired taste or smell. This study aimed to evaluate the presence of SARS-CoV-2 in cerebrospinal fluid (CSF) from suspected cases of meningitis. During the first year of the pandemic, from January 2020 to February 2021, CSF samples were first submitted to multiplex qPCR to detect the three main bacteria causing meningitis (Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae), as the routine of the laboratory, but also, they were submitted to RT-qPCR to SARS-CoV-2 detection. Some samples (20 %) were positive for one bacterium; however, none were positive for the virus, suggesting that the incidence of SARS-CoV-2 in meninges is extremely low. This study with other data in the literature contributes to the epidemiologic surveillance of SARS-CoV-2. |
| format | Article |
| id | doaj-art-3d98a8bb0fbb4a08be099a212e7740e1 |
| institution | Kabale University |
| issn | 1413-8670 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj-art-3d98a8bb0fbb4a08be099a212e7740e12025-08-20T03:43:55ZengElsevierBrazilian Journal of Infectious Diseases1413-86702025-09-0129510457110.1016/j.bjid.2025.104571SARS-CoV-2 investigation in cerebrospinal fluid from meningitis patients during the first pandemic waveMaria Cecilia Cergole-Novella0Thayná Rosa Bispo1Elaine Monteiro Matsuda2Daniela Rodrigues Colpas3Ivana Barros de Campos4Instituto Adolfo Lutz, Centro de Laboratório Regional Santo André, Santo André, SP, BrazilInstituto Adolfo Lutz, Centro de Laboratório Regional Santo André, Santo André, SP, BrazilPrefeitura Municipal de Santo André, Secretaria de Saúde de Santo André, Santo André, SP, BrazilInstituto Adolfo Lutz, Centro de Laboratório Regional Santo André, Santo André, SP, BrazilInstituto Adolfo Lutz, Centro de Laboratório Regional Santo André, Santo André, SP, Brazil; Corresponding author.SARS-CoV-2 predominantly affects the respiratory system; however, during the first pandemic wave, there was a concern about its neuroinvasive potential due to its ability to replicate in neural cells and the neurological signs widely reported as impaired taste or smell. This study aimed to evaluate the presence of SARS-CoV-2 in cerebrospinal fluid (CSF) from suspected cases of meningitis. During the first year of the pandemic, from January 2020 to February 2021, CSF samples were first submitted to multiplex qPCR to detect the three main bacteria causing meningitis (Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae), as the routine of the laboratory, but also, they were submitted to RT-qPCR to SARS-CoV-2 detection. Some samples (20 %) were positive for one bacterium; however, none were positive for the virus, suggesting that the incidence of SARS-CoV-2 in meninges is extremely low. This study with other data in the literature contributes to the epidemiologic surveillance of SARS-CoV-2.http://www.sciencedirect.com/science/article/pii/S1413867025000728SARS-CoV-2RT-qPCRMeningitisCerebrospinal fluid |
| spellingShingle | Maria Cecilia Cergole-Novella Thayná Rosa Bispo Elaine Monteiro Matsuda Daniela Rodrigues Colpas Ivana Barros de Campos SARS-CoV-2 investigation in cerebrospinal fluid from meningitis patients during the first pandemic wave Brazilian Journal of Infectious Diseases SARS-CoV-2 RT-qPCR Meningitis Cerebrospinal fluid |
| title | SARS-CoV-2 investigation in cerebrospinal fluid from meningitis patients during the first pandemic wave |
| title_full | SARS-CoV-2 investigation in cerebrospinal fluid from meningitis patients during the first pandemic wave |
| title_fullStr | SARS-CoV-2 investigation in cerebrospinal fluid from meningitis patients during the first pandemic wave |
| title_full_unstemmed | SARS-CoV-2 investigation in cerebrospinal fluid from meningitis patients during the first pandemic wave |
| title_short | SARS-CoV-2 investigation in cerebrospinal fluid from meningitis patients during the first pandemic wave |
| title_sort | sars cov 2 investigation in cerebrospinal fluid from meningitis patients during the first pandemic wave |
| topic | SARS-CoV-2 RT-qPCR Meningitis Cerebrospinal fluid |
| url | http://www.sciencedirect.com/science/article/pii/S1413867025000728 |
| work_keys_str_mv | AT mariaceciliacergolenovella sarscov2investigationincerebrospinalfluidfrommeningitispatientsduringthefirstpandemicwave AT thaynarosabispo sarscov2investigationincerebrospinalfluidfrommeningitispatientsduringthefirstpandemicwave AT elainemonteiromatsuda sarscov2investigationincerebrospinalfluidfrommeningitispatientsduringthefirstpandemicwave AT danielarodriguescolpas sarscov2investigationincerebrospinalfluidfrommeningitispatientsduringthefirstpandemicwave AT ivanabarrosdecampos sarscov2investigationincerebrospinalfluidfrommeningitispatientsduringthefirstpandemicwave |