Dressing Influence on Re-epithelialization Rate Following Split-thickness Skin Graft Harvest: Network Meta-analysis of Randomized Controlled Trials
Background:. More than 160,000 skin grafts are performed annually in approximately 1 out of every 3 burn hospitalizations individually because they are primarily simple and quick. This network meta-analysis aimed to compare different conventional dressing options based on re-epithelialization time a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2025-05-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006748 |
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| author | Nawaf Alhindi, MBBS Sarah Qari, MBBS Houriah Nukaly, MBBS Abdullah Althagafi, MBBS Sarah Alzolaibani, MBBS Mousa Akkour, MBBS Kausar Ahmed, MBBS Abdulaziz Samandar, MBBS Abdulaziz Alsuhaim, MBBS Hanin Banjer, MBBS Feryal Alali, MBBS Assal Hobani, MBBS Abdulaziz Altala, MBBS Zainab Alasfour, MBBS Khalid Arab, MD, FRCS(C) |
| author_facet | Nawaf Alhindi, MBBS Sarah Qari, MBBS Houriah Nukaly, MBBS Abdullah Althagafi, MBBS Sarah Alzolaibani, MBBS Mousa Akkour, MBBS Kausar Ahmed, MBBS Abdulaziz Samandar, MBBS Abdulaziz Alsuhaim, MBBS Hanin Banjer, MBBS Feryal Alali, MBBS Assal Hobani, MBBS Abdulaziz Altala, MBBS Zainab Alasfour, MBBS Khalid Arab, MD, FRCS(C) |
| author_sort | Nawaf Alhindi, MBBS |
| collection | DOAJ |
| description | Background:. More than 160,000 skin grafts are performed annually in approximately 1 out of every 3 burn hospitalizations individually because they are primarily simple and quick. This network meta-analysis aimed to compare different conventional dressing options based on re-epithelialization time and side effects for split-thickness skin graft donor sites.
Methods:. As per preferred reporting items for systematic reviews and meta-analysis guidelines, a thorough systematic review and network meta-analysis were conducted. A comprehensive search was performed using MEDLINE, Cochrane, and Embase databases, and all publications published before August 2023 were included without time restrictions.
Results:. This study performed a network meta-analysis of 25 unique randomized controlled trials published between 1983 and 2022. We found that alginate is the most often used, followed by paraffin gauze. Nonetheless, povidone-iodine-impregnated foam (Betafoam) was the most effective (90.4%), followed by hydrocolloid (87.9%). Petrolatum (73.5%) is associated with faster re-epithelialization than alginate (40.6%) and paraffin (18.1%). Cotton gauze ranked as the worst modality for skin graft donor-site dressing (3.9%).
Conclusions:. This study serves as a guide for the selection of proper dressing for patients undergoing partial-thickness skin graft harvest. Even though povidone-iodine-impregnated foam was the most effective, we recommend further research comparing other factors for selecting dressings, such as wound and patient characteristics, availability, and costs of dressings. |
| format | Article |
| id | doaj-art-3d7c851b3e8448f4b6b6409f9d087f86 |
| institution | Kabale University |
| issn | 2169-7574 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj-art-3d7c851b3e8448f4b6b6409f9d087f862025-08-20T03:48:22ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742025-05-01135e674810.1097/GOX.0000000000006748202505000-00041Dressing Influence on Re-epithelialization Rate Following Split-thickness Skin Graft Harvest: Network Meta-analysis of Randomized Controlled TrialsNawaf Alhindi, MBBS0Sarah Qari, MBBS1Houriah Nukaly, MBBS2Abdullah Althagafi, MBBS3Sarah Alzolaibani, MBBS4Mousa Akkour, MBBS5Kausar Ahmed, MBBS6Abdulaziz Samandar, MBBS7Abdulaziz Alsuhaim, MBBS8Hanin Banjer, MBBS9Feryal Alali, MBBS10Assal Hobani, MBBS11Abdulaziz Altala, MBBS12Zainab Alasfour, MBBS13Khalid Arab, MD, FRCS(C)14From the * Saudi Ministry of Health, Rabigh, Saudi Arabia† Faculty of Medicine, Ibn Sina Medical College, Jeddah, Saudi Arabia‡ Faculty of Medicine, Batterjee Medical College, Jeddah, Saudi ArabiaFrom the * Saudi Ministry of Health, Rabigh, Saudi Arabia§ Faculty of Medicine, Taibah University, Madinah, Saudi Arabia¶ Division of Plastic Surgery, Department of Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia∥ Faculty of Medicine, Fakeeh Medical College, Jeddah, Saudi Arabia** Faculty of Medicine, Umm-AlQura University, Makkah, Saudi Arabia†† Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia‡‡ Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia‡‡ Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia† Faculty of Medicine, Ibn Sina Medical College, Jeddah, Saudi Arabia§§ Faculty of Medicine, Dar AlUloom Medical College, Riyadh, Saudi Arabia¶¶ Faculty of Medicine, King Faisal University, Alahsa, Saudi Arabia∥∥ Division of Plastic Surgery, Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.Background:. More than 160,000 skin grafts are performed annually in approximately 1 out of every 3 burn hospitalizations individually because they are primarily simple and quick. This network meta-analysis aimed to compare different conventional dressing options based on re-epithelialization time and side effects for split-thickness skin graft donor sites. Methods:. As per preferred reporting items for systematic reviews and meta-analysis guidelines, a thorough systematic review and network meta-analysis were conducted. A comprehensive search was performed using MEDLINE, Cochrane, and Embase databases, and all publications published before August 2023 were included without time restrictions. Results:. This study performed a network meta-analysis of 25 unique randomized controlled trials published between 1983 and 2022. We found that alginate is the most often used, followed by paraffin gauze. Nonetheless, povidone-iodine-impregnated foam (Betafoam) was the most effective (90.4%), followed by hydrocolloid (87.9%). Petrolatum (73.5%) is associated with faster re-epithelialization than alginate (40.6%) and paraffin (18.1%). Cotton gauze ranked as the worst modality for skin graft donor-site dressing (3.9%). Conclusions:. This study serves as a guide for the selection of proper dressing for patients undergoing partial-thickness skin graft harvest. Even though povidone-iodine-impregnated foam was the most effective, we recommend further research comparing other factors for selecting dressings, such as wound and patient characteristics, availability, and costs of dressings.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006748 |
| spellingShingle | Nawaf Alhindi, MBBS Sarah Qari, MBBS Houriah Nukaly, MBBS Abdullah Althagafi, MBBS Sarah Alzolaibani, MBBS Mousa Akkour, MBBS Kausar Ahmed, MBBS Abdulaziz Samandar, MBBS Abdulaziz Alsuhaim, MBBS Hanin Banjer, MBBS Feryal Alali, MBBS Assal Hobani, MBBS Abdulaziz Altala, MBBS Zainab Alasfour, MBBS Khalid Arab, MD, FRCS(C) Dressing Influence on Re-epithelialization Rate Following Split-thickness Skin Graft Harvest: Network Meta-analysis of Randomized Controlled Trials Plastic and Reconstructive Surgery, Global Open |
| title | Dressing Influence on Re-epithelialization Rate Following Split-thickness Skin Graft Harvest: Network Meta-analysis of Randomized Controlled Trials |
| title_full | Dressing Influence on Re-epithelialization Rate Following Split-thickness Skin Graft Harvest: Network Meta-analysis of Randomized Controlled Trials |
| title_fullStr | Dressing Influence on Re-epithelialization Rate Following Split-thickness Skin Graft Harvest: Network Meta-analysis of Randomized Controlled Trials |
| title_full_unstemmed | Dressing Influence on Re-epithelialization Rate Following Split-thickness Skin Graft Harvest: Network Meta-analysis of Randomized Controlled Trials |
| title_short | Dressing Influence on Re-epithelialization Rate Following Split-thickness Skin Graft Harvest: Network Meta-analysis of Randomized Controlled Trials |
| title_sort | dressing influence on re epithelialization rate following split thickness skin graft harvest network meta analysis of randomized controlled trials |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006748 |
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