GABAAR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation

GABAAR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation

Abstract The infantile neuronal ceroid lipofuscinosis, also called CLN1 disease, is a fatal neurodegenerative disease caused by mutations in the CLN1 gene encoding palmitoyl protein thioesterase 1 (PPT1). Identifying the depalmitoylation substrates of PPT1 is crucial for understanding CLN1 disease....

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Main Authors: Jia Tong, Jingjing Gao, Yawei Qi, Ziyan Gao, Qianqian Wang, Yang Liu, Tiangang Yuan, Minglong Ren, Guixia Yang, Zhaoyue Li, Jin Li, Hongyuan Sun, Xing Zhao, Yeung-Yeung Leung, Yonghui Mu, Jiamin Xu, Chengbiao Lu, Shiyong Peng, Lihao Ge
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-024-03206-1
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https://doi.org/10.1038/s41398-024-03206-1

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