Closed-loop two-photon functional imaging in a freely moving animal

Abstract Direct measurement of neural activity in freely moving animals is essential for understanding how the brain controls and represents behaviors. Genetically encoded calcium indicators report neural activity as changes in fluorescence intensity, but brain motion confounds quantitative measurem...

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Bibliographic Details
Main Authors: Paul McNulty, Rui Wu, Akihiro Yamaguchi, Ellie S. Heckscher, Andrew Haas, Amajindi Nwankpa, Mirna Mihovilovic Skanata, and Marc Gershow
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60648-x
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