SMARCA5 is required for the development of granule cell neuron precursors and Sonic Hedgehog Medulloblastoma growth

SMARCA5 is required for the development of granule cell neuron precursors and Sonic Hedgehog Medulloblastoma growth

Abstract Medulloblastoma constitutes a molecularly diverse group of malignant embryonal brain tumors. Sonic hedgehog molecular group of medulloblastoma (SHH-MB) is a highly heterogeneous tumor entity, characterized by constitutive activation of the SHH signaling pathway. Due to lack of suitable cell...

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Bibliographic Details
Main Authors: Foteini Tsiami, Layla Drwesh, Surender Surender, Julia Fitzgerald, Jens Schittenhelm, David J. Picketts, Rosalind A. Segal, Ghazaleh Tabatabai, Daniel J. Merk
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Sonic Hedgehog Medulloblastoma
SMARCA5
Granule neuron precursors
Cerebellar development
Online Access:https://doi.org/10.1038/s41598-025-11857-3
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https://doi.org/10.1038/s41598-025-11857-3

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