Insights into the roles of exogenous phenylalanine and tyrosine in improving rapamycin production of Streptomyces rapamycinicus with transcriptome analysis

Insights into the roles of exogenous phenylalanine and tyrosine in improving rapamycin production of Streptomyces rapamycinicus with transcriptome analysis

Abstract Rapamycin is an important natural macrolide antibiotic with antifungal, immunosuppressive and antitumor activities produced by Streptomyces rapamycinicus. However, their prospective applications are limited by low fermentation units. In this study, we found that the exogenous aromatic amino...

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Bibliographic Details
Main Authors: Dongmei Xu, Yaoyao Wang, Hongzhen Li, Bing Wang, Libin Chai, Li Feng, Fengzhi Ren, Xuejin Zhao, Xuexia Zhang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Microbial Cell Factories
Subjects:
Rapamycin
Streptomyces
Phenylalanine and tyrosine
Transcriptome
Online Access:https://doi.org/10.1186/s12934-024-02632-6
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