Automated, aseptic sampling with small-volume capacity from microbioreactors for cell therapy process analysis

Automated, aseptic sampling with small-volume capacity from microbioreactors for cell therapy process analysis

Current workflows in autologous cell therapy manufacturing are reliant on manual processes that are difficult to scale out to meet patient demands. High throughput bioreactor systems that enable multiple cultures to occur in parallel can address this need, but require good bioprocess monitoring work...

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Bibliographic Details
Main Authors: Zhi Xian Chan, Shruthi Pandi Chelvam, Wei-Xiang Sin, Denise Bei Lin Teo, Ahmad Amirul Bin Abdul Rahim, Ying Ying Wu, Dan Liu, Michael E. Birnbaum, Derrick Yong, Rajeev J. Ram
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
autosampler
aseptic
small-volume
car-t
bioreactor
microbioreactor
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1612648/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1612648/full

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