Homoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarction
Abstract Early depressive symptoms within the first days after acute myocardial infarction (AMI) are mainly manifested with performance parameters (lack of energy, concentration difficulties, reduction in physical functioning). Homoarginine (hArg), a non-proteinogenic amino acid, might increase the...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84930-y |
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| author | Andreas Baranyi Andreas Meinitzer Dirk von Lewinski Jolana Wagner-Skacel Sabrina Leal Garcia Hans-Bernd Rothenhäusler Omid Amouzadeh-Ghadikolai Leonhard Harpf Melanie Schweinzer Dietmar Enko |
| author_facet | Andreas Baranyi Andreas Meinitzer Dirk von Lewinski Jolana Wagner-Skacel Sabrina Leal Garcia Hans-Bernd Rothenhäusler Omid Amouzadeh-Ghadikolai Leonhard Harpf Melanie Schweinzer Dietmar Enko |
| author_sort | Andreas Baranyi |
| collection | DOAJ |
| description | Abstract Early depressive symptoms within the first days after acute myocardial infarction (AMI) are mainly manifested with performance parameters (lack of energy, concentration difficulties, reduction in physical functioning). Homoarginine (hArg), a non-proteinogenic amino acid, might increase the availability of nitric oxide (NO). NO controls vasodilatation, blood flow, mitochondrial respiration and improves performance. Therefore, low plasma hArg levels after an AMI might impact performance-related early depressive symptoms. This longitudinal study aims to determine the course of plasma hArg concentrations immediately, on the fourth day and 6 months after AMI and investigates the associations between hArg and early depressive symptoms. A decrease in hArg levels, as observed in AMI patients on the fourth day after AMI, was independent of gender, age, body-mass-index and AMI type. After six months, hArg concentrations no longer differed significantly from baseline values. Females had lower hArg concentrations shortly after and also four days after the AMI compared to males. Within the first days after AMI HAMD-17 and BDI-II total depression scores and performance-related early depressive symptoms such as lack of energy, concentration difficulties and reduction in physical functioning correlated with low hArg concentrations. |
| format | Article |
| id | doaj-art-3cdac11145ef4e6080419d8e7f207a74 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-3cdac11145ef4e6080419d8e7f207a742025-01-12T12:18:30ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-024-84930-yHomoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarctionAndreas Baranyi0Andreas Meinitzer1Dirk von Lewinski2Jolana Wagner-Skacel3Sabrina Leal Garcia4Hans-Bernd Rothenhäusler5Omid Amouzadeh-Ghadikolai6Leonhard Harpf7Melanie Schweinzer8Dietmar Enko9Department of Psychiatry, Psychosomatics and Psychotherapeutic Medicine, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of GrazClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of GrazDepartment of Internal Medicine, Division of Cardiology, Medical University of GrazDepartment of Psychiatry, Psychosomatics and Psychotherapeutic Medicine, Division of Medical Psychology, Psychosomatics and Psychotherapeutic MedicineDepartment of Psychiatry, Psychosomatics and Psychotherapeutic Medicine, Division of Medical Psychology, Psychosomatics and Psychotherapeutic MedicineDepartment of Psychiatry, Psychosomatics and Psychotherapeutic Medicine, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of GrazGFSG - Gesellschaft Zur Förderung Seelischer Gesundheit GmbHPRO-DOCDepartment of Psychiatry, Psychosomatics and Psychotherapeutic Medicine, Division of Psychiatry and Psychotherapeutic Medicine, Medical University of GrazClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of GrazAbstract Early depressive symptoms within the first days after acute myocardial infarction (AMI) are mainly manifested with performance parameters (lack of energy, concentration difficulties, reduction in physical functioning). Homoarginine (hArg), a non-proteinogenic amino acid, might increase the availability of nitric oxide (NO). NO controls vasodilatation, blood flow, mitochondrial respiration and improves performance. Therefore, low plasma hArg levels after an AMI might impact performance-related early depressive symptoms. This longitudinal study aims to determine the course of plasma hArg concentrations immediately, on the fourth day and 6 months after AMI and investigates the associations between hArg and early depressive symptoms. A decrease in hArg levels, as observed in AMI patients on the fourth day after AMI, was independent of gender, age, body-mass-index and AMI type. After six months, hArg concentrations no longer differed significantly from baseline values. Females had lower hArg concentrations shortly after and also four days after the AMI compared to males. Within the first days after AMI HAMD-17 and BDI-II total depression scores and performance-related early depressive symptoms such as lack of energy, concentration difficulties and reduction in physical functioning correlated with low hArg concentrations.https://doi.org/10.1038/s41598-024-84930-yAcute myocardial infarctionHomoarginineEarly depressive symptomsPhysical functioning |
| spellingShingle | Andreas Baranyi Andreas Meinitzer Dirk von Lewinski Jolana Wagner-Skacel Sabrina Leal Garcia Hans-Bernd Rothenhäusler Omid Amouzadeh-Ghadikolai Leonhard Harpf Melanie Schweinzer Dietmar Enko Homoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarction Scientific Reports Acute myocardial infarction Homoarginine Early depressive symptoms Physical functioning |
| title | Homoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarction |
| title_full | Homoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarction |
| title_fullStr | Homoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarction |
| title_full_unstemmed | Homoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarction |
| title_short | Homoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarction |
| title_sort | homoarginine concentrations correlate with early depressive symptoms and the reduction in physical functioning within the first days after myocardial infarction |
| topic | Acute myocardial infarction Homoarginine Early depressive symptoms Physical functioning |
| url | https://doi.org/10.1038/s41598-024-84930-y |
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