Sustained immune activation and impaired epithelial barrier integrity in the ectocervix of women with chronic HIV infection.

Sustained immune activation and impaired epithelial barrier integrity in the ectocervix of women with chronic HIV infection.

Chronic systemic immune activation significantly influences human immunodeficiency virus (HIV) disease progression. Despite evidence of a pro-inflammatory environment in the genital tract of HIV-infected women, comprehensive investigations into cervical tissue from this region remain limited. Simila...

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Main Authors: Mathias Franzén Boger, Tyra Hasselrot, Vilde Kaldhusdal, Gisele H B Miranda, Paulo Czarnewski, Gabriella Edfeldt, Frideborg Bradley, Genta Rexaj, Julie Lajoie, Kenneth Omollo, Joshua Kimani, Keith R Fowke, Kristina Broliden, Annelie Tjernlund
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012709
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https://doi.org/10.1371/journal.ppat.1012709

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