Sceptic: pseudotime analysis for time-series single-cell sequencing and imaging data

Abstract Several computational methods have been developed to construct single-cell pseudotime embeddings for extracting the temporal order of transcriptional cell states from time-series scRNA-seq datasets. However, existing methods suffer from low predictive accuracy, and this problem becomes even...

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Bibliographic Details
Main Authors: Gang Li, Hyeon-Jin Kim, Sriram Pendyala, Ran Zhang, Jean-Philippe Vert, Christine M. Disteche, Xinxian Deng, Douglas M. Fowler, William Stafford Noble
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-025-03679-3
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