Anticancer activity of triterpene glycosides from the sea star Solaster pacificus

Anticancer activity of triterpene glycosides from the sea star Solaster pacificus

Abstract Marine triterpene glycosides are known to exhibit significant anticancer activity. We investigated pacificusoside C and cucumariosides C1 and C2 isolated from a sea star Solaster pacificus in prostate cancer models with varying drug resistance and in non-cancerous cells in vitro. Cucumarios...

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Main Authors: Sergey A. Dyshlovoy, Jessica Hauschild, Malte Kriegs, Konstantin Hoffer, Olga Y. Burenina, Nadja Strewinsky, Timofey V. Malyarenko, Alla A. Kicha, Natalia V. Ivanchina, Valentin A. Stonik, Markus Graefen, Carsten Bokemeyer, Gunhild von Amsberg
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Triterpene glycosides
Prostate cancer
Solaster pacificus
Marine natural compounds
P-glycoprotein
MAPK
Online Access:https://doi.org/10.1038/s41598-025-12914-7
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https://doi.org/10.1038/s41598-025-12914-7

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