Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application

Abstract The dynamic regulation of chromatin accessibility is one of the prominent characteristics of eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which is multilevel compressed and access restricted. The remaining accessible loci are generally located in the eu...

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Bibliographic Details
Main Authors: Yang Chen, Rui Liang, Yong Li, Lingli Jiang, Di Ma, Qing Luo, Guanbin Song
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-024-02030-9
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