Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway

Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway

Abstract Background In China, Tongguanteng injection (TGT) is widely used in the treatment or adjuvant treatment of various types of cancer. However, the effect and mechanism of TGT in osteosarcoma is not clear. Methods The 143B and MG-63 cells were treated with different concentrations of TGT. Cell...

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Main Authors: Xiao-Chuan Xue, Yang-Yun Zhou, Ling-Yan Xu, Lan-Yi Wei, Yu-Jie Hu, Jiao Yang, Xiang-Qi Zhang, Meng-Yue Wang, Yong-Long Han, Jun-Jun Chen
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Tongguanteng injection
Osteosarcoma
Apoptosis
ER stress
IRE1/CHOP pathway
Online Access:https://doi.org/10.1186/s12906-024-04689-7
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https://doi.org/10.1186/s12906-024-04689-7

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