Late-stage O-sulfation with a bioinspired sulfuryl donor

Abstract O-sulfation is a widespread modification of both endogenous and exogenous biomolecules, where the primary objective is to identify effective sulfuryl donors. In nature, 3′-phosphoadenosine-5′-phosphosulfate (PAPS) and p-nitrophenyl sulfate (PNPS) are efficient sulfuryl donors. However, most...

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Bibliographic Details
Main Authors: Ye Zheng, Li Huang, Chunlan Song, Jiakun Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62093-2
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