RAG recombinase expression discriminates the development of natural killer cells

RAG recombinase expression discriminates the development of natural killer cells

IntroductionV(D)J recombination, initiated by recombination-activating gene (RAG) endonucleases, is a crucial process for the generation of diversified antigen receptors of T and B lymphocytes but regarded dispensable for innate natural killer (NK) lymphocytes lacking clonotypic receptors.MethodsTo...

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Main Authors: Jasmin Sprissler, Ulrich Pannicke, Eva-Maria Rump, Hubert Schrezenmeier, Nicolas Casadei, Michaela Pogoda, Laurence Kuhlburger, Morgana Barroso Oquendo, Stefan Czemmel, Klaus-Michael Debatin, Miriam Erlacher, Klaus Schwarz, Kerstin Felgentreff
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
RAG-fate reporter
induced pluripotent stem cells
NK cell differentiation
V(D)J recombination
DNA damage response
lymphoid progenitor cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607664/full
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