Rebalancing translaminar pressure difference: a novel glaucoma surgery—a pilot trial in non-human primates
AIM: To propose a novel glaucoma surgery for rebalancing translaminar pressure difference. METHODS: Three non-human primates with normal eyes and two with laser-induced glaucoma underwent the novel surgical procedure. Cannulation of the subarachnoid space was performed after completion of routine vi...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-09-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/9/20250902.pdf |
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| author | Chen Xin Qing Sang Shen Wu Rui-Qi Pang Dan-Ting Lin Huai-Zhou Wang Ning Lu Ning-Li Wang |
| author_facet | Chen Xin Qing Sang Shen Wu Rui-Qi Pang Dan-Ting Lin Huai-Zhou Wang Ning Lu Ning-Li Wang |
| author_sort | Chen Xin |
| collection | DOAJ |
| description | AIM: To propose a novel glaucoma surgery for rebalancing translaminar pressure difference. METHODS: Three non-human primates with normal eyes and two with laser-induced glaucoma underwent the novel surgical procedure. Cannulation of the subarachnoid space was performed after completion of routine vitrectomy steps. An XEN 45 implant was inserted into the created puncture to communicate between the vitreous body and subarachnoid space. Intraocular pressure (IOP), fundus photography, and spectral-domain optical coherence tomography were assessed at baseline and regular intervals during follow-up. RESULTS: All operated eyes showed IOP reduction in the first postoperative month. Two (2/3) normal eyes and one (1/2) glaucomatous eye maintained lower IOP until 18mo after operation. The XEN 45 implant remained positioned through the lamina cribrosa in all normal eyes but was not detected in two glaucomatous eyes. Complications observed in this study included retinal vascular bleeding in 1/3 normal eyes and XEN implant dislocation in all 2 glaucomatous eyes. CONCLUSION: Subarachnoid space cannulation and mini-shunt implantation may contribute to IOP reduction, possibly by rebalancing translaminar pressure difference and enhancing aqueous humor drainage. The development of a suitable mini-shunt requires further investigation. |
| format | Article |
| id | doaj-art-3ba09d29606b4bb38bd8c29f1be38cde |
| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-3ba09d29606b4bb38bd8c29f1be38cde2025-08-22T06:07:08ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-09-011891619162510.18240/ijo.2025.09.0220250902Rebalancing translaminar pressure difference: a novel glaucoma surgery—a pilot trial in non-human primatesChen Xin0Qing Sang1Shen Wu2Rui-Qi Pang3Dan-Ting Lin4Huai-Zhou Wang5Ning Lu6Ning-Li Wang7Ning-Li Wang. Beijing Tongren Hospital, 1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China. wningli@vip.163.comBeijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing 102218, ChinaBeijing Institution of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Institution of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaAIM: To propose a novel glaucoma surgery for rebalancing translaminar pressure difference. METHODS: Three non-human primates with normal eyes and two with laser-induced glaucoma underwent the novel surgical procedure. Cannulation of the subarachnoid space was performed after completion of routine vitrectomy steps. An XEN 45 implant was inserted into the created puncture to communicate between the vitreous body and subarachnoid space. Intraocular pressure (IOP), fundus photography, and spectral-domain optical coherence tomography were assessed at baseline and regular intervals during follow-up. RESULTS: All operated eyes showed IOP reduction in the first postoperative month. Two (2/3) normal eyes and one (1/2) glaucomatous eye maintained lower IOP until 18mo after operation. The XEN 45 implant remained positioned through the lamina cribrosa in all normal eyes but was not detected in two glaucomatous eyes. Complications observed in this study included retinal vascular bleeding in 1/3 normal eyes and XEN implant dislocation in all 2 glaucomatous eyes. CONCLUSION: Subarachnoid space cannulation and mini-shunt implantation may contribute to IOP reduction, possibly by rebalancing translaminar pressure difference and enhancing aqueous humor drainage. The development of a suitable mini-shunt requires further investigation.http://ies.ijo.cn/en_publish/2025/9/20250902.pdftranslaminar pressure differenceglaucoma surgerylamina cribrosaintraocular pressure |
| spellingShingle | Chen Xin Qing Sang Shen Wu Rui-Qi Pang Dan-Ting Lin Huai-Zhou Wang Ning Lu Ning-Li Wang Rebalancing translaminar pressure difference: a novel glaucoma surgery—a pilot trial in non-human primates International Journal of Ophthalmology translaminar pressure difference glaucoma surgery lamina cribrosa intraocular pressure |
| title | Rebalancing translaminar pressure difference: a novel glaucoma surgery—a pilot trial in non-human primates |
| title_full | Rebalancing translaminar pressure difference: a novel glaucoma surgery—a pilot trial in non-human primates |
| title_fullStr | Rebalancing translaminar pressure difference: a novel glaucoma surgery—a pilot trial in non-human primates |
| title_full_unstemmed | Rebalancing translaminar pressure difference: a novel glaucoma surgery—a pilot trial in non-human primates |
| title_short | Rebalancing translaminar pressure difference: a novel glaucoma surgery—a pilot trial in non-human primates |
| title_sort | rebalancing translaminar pressure difference a novel glaucoma surgery a pilot trial in non human primates |
| topic | translaminar pressure difference glaucoma surgery lamina cribrosa intraocular pressure |
| url | http://ies.ijo.cn/en_publish/2025/9/20250902.pdf |
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