Endothelial delivery of simvastatin by LRP1-targeted nanoparticles ameliorates pathogenesis of alzheimer’s disease in a mouse model

Endothelial delivery of simvastatin by LRP1-targeted nanoparticles ameliorates pathogenesis of alzheimer’s disease in a mouse model

Abstract Blood-brain barrier (BBB) dysfunction is an early pathological hallmark of Alzheimer’s disease (AD), occurring prior to amyloid-β (Aβ) accumulation. A key factor contributing to BBB damage in AD is the loss of endothelial expression of low-density lipoprotein receptor-related protein 1 (LRP...

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Main Authors: Ting-Ting Pan, Yan-Yun Sun, Yi-Fan Shi, Mei Zhao, Naveed Ullah Khan, Hai-Yan Chen, Wen-Li Ji, Jie Li, Liang Han, Quan-Hong Ma
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Simvastatin
Nanoparticles
Alzheimer’s disease
LRP1
BBB
Amyloid-β
Online Access:https://doi.org/10.1186/s13195-025-01840-5
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https://doi.org/10.1186/s13195-025-01840-5

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