Single-cell and bulk transcriptome profiling reveals RNA-binding protein regulatory programs in cervical cancer

Single-cell and bulk transcriptome profiling reveals RNA-binding protein regulatory programs in cervical cancer

Abstract The aberrant expression of RNA binding proteins (RBPs) is linked to various diseases, including cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). However, the single-cell landscape of RBPs in CESC remains unclear. We analyzed single-cell data from 2 HPV + and 2 HPV- C...

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Bibliographic Details
Main Authors: Shasha Yang, Jingjing Zeng, Yong Wang, Yudi Tan, Li Yu, Jinkong Wei, Yuying Wei, Yuxuan Jin, Junying Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Alternative splicing
Cervical cancer
Epithelial cell
RNA binding proteins
ScRNA-seq
Online Access:https://doi.org/10.1038/s41598-025-14823-1
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