A method for identifying neoantigens through isolation of circulating tumor cells using apheresis among patients with advanced-stage cancer

A method for identifying neoantigens through isolation of circulating tumor cells using apheresis among patients with advanced-stage cancer

BackgroundImmune checkpoint inhibitors show limited efficacy in tumors with low tumor mutational burden, partly due to insufficient neoantigen presentation.MethodsWe developed a novel approach for neoantigen identification using circulating tumor cells (CTCs) isolated via leukapheresis and flow cyto...

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Bibliographic Details
Main Authors: Daiki Kobayashi, Takuya Kosumi, Queenie Lai Kwan Lam, Shigeharu Fujita, Yasuki Hijikata, Kaori Takeda, Tomoya Narita, Naomi Yamashita, Guilhem Richard, Anne S. De Groot, Naohide Yamashita
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
apheresis
CTC
neoantigen
CD45
EpCAM
Vimentin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609116/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609116/full

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