Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study
PurposeSarcopenia, an age-related complication, constitutes a major public health problem given the aging of the population. However, it is frequently overlooked and undertreated in mainstream practice. The study aimed to investigate the correlations between triglyceride-glucose (TyG) index and TyG-...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1475330/full |
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| author | Min Li Ying Liu Lei Gao Yongli Zheng Luyao Chen Yan Wang Wei Zhang |
| author_facet | Min Li Ying Liu Lei Gao Yongli Zheng Luyao Chen Yan Wang Wei Zhang |
| author_sort | Min Li |
| collection | DOAJ |
| description | PurposeSarcopenia, an age-related complication, constitutes a major public health problem given the aging of the population. However, it is frequently overlooked and undertreated in mainstream practice. The study aimed to investigate the correlations between triglyceride-glucose (TyG) index and TyG-body mass index (BMI) and sarcopenia in non-diabetic middle-aged and older women and whether they would be helpful indicators of sarcopenia.Patients and methodsThis cross-sectional study was conducted in the Department of Endocrinology, Hebei Medical University Third Hospital. This study prospectively enrolled 460 non-diabetic postmenopausal women aged ≥50 years.ResultsAs TyG and TyG-BMI increased, the prevalence of sarcopenia decreased. In multivariate analysis, the TyG index and TyG-BMI index were inversely associated with sarcopenia (OR: 0.492; 95% CI: 0.256–0.944 and OR: 0.948; 95% CI: 0.934–0.962). Women in the fourth TyG-BMI quartiles showed decreased OR of 0.009 (95% CI: 0.001–0.072) for sarcopenia with respect to first quartiles after adjusting confounding factors. The area under the curve (AUC) for TyG index in the diagnosis of sarcopenia was 0.598 (95% CI: 0.529–0.666), while the AUC for TyG-BMI index was 0.858 (95% CI: 0.816–0.899).ConclusionHigher TyG index and TyG-BMI index protected against sarcopenia in non-diabetic middle-aged and older females. Moreover, the TyG-BMI index was a reliable and cost-efficient biomarker to predict sarcopenia. |
| format | Article |
| id | doaj-art-3b4e9f1c289548d69c3a0c335dfdee99 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-3b4e9f1c289548d69c3a0c335dfdee992025-01-07T06:50:34ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011210.3389/fpubh.2024.14753301475330Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional studyMin Li0Ying Liu1Lei Gao2Yongli Zheng3Luyao Chen4Yan Wang5Wei Zhang6Department of Endocrinology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, ChinaDepartment of Radiology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, ChinaDepartment of Radiology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, ChinaDepartment of Radiology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, ChinaDepartment of Radiology, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, ChinaPurposeSarcopenia, an age-related complication, constitutes a major public health problem given the aging of the population. However, it is frequently overlooked and undertreated in mainstream practice. The study aimed to investigate the correlations between triglyceride-glucose (TyG) index and TyG-body mass index (BMI) and sarcopenia in non-diabetic middle-aged and older women and whether they would be helpful indicators of sarcopenia.Patients and methodsThis cross-sectional study was conducted in the Department of Endocrinology, Hebei Medical University Third Hospital. This study prospectively enrolled 460 non-diabetic postmenopausal women aged ≥50 years.ResultsAs TyG and TyG-BMI increased, the prevalence of sarcopenia decreased. In multivariate analysis, the TyG index and TyG-BMI index were inversely associated with sarcopenia (OR: 0.492; 95% CI: 0.256–0.944 and OR: 0.948; 95% CI: 0.934–0.962). Women in the fourth TyG-BMI quartiles showed decreased OR of 0.009 (95% CI: 0.001–0.072) for sarcopenia with respect to first quartiles after adjusting confounding factors. The area under the curve (AUC) for TyG index in the diagnosis of sarcopenia was 0.598 (95% CI: 0.529–0.666), while the AUC for TyG-BMI index was 0.858 (95% CI: 0.816–0.899).ConclusionHigher TyG index and TyG-BMI index protected against sarcopenia in non-diabetic middle-aged and older females. Moreover, the TyG-BMI index was a reliable and cost-efficient biomarker to predict sarcopenia.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1475330/fullsarcopeniatriglyceride-glucose indextriglyceride glucose-body mass indexinsulin resistancemiddle-aged and older non-diabetic women |
| spellingShingle | Min Li Ying Liu Lei Gao Yongli Zheng Luyao Chen Yan Wang Wei Zhang Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study Frontiers in Public Health sarcopenia triglyceride-glucose index triglyceride glucose-body mass index insulin resistance middle-aged and older non-diabetic women |
| title | Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study |
| title_full | Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study |
| title_fullStr | Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study |
| title_full_unstemmed | Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study |
| title_short | Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study |
| title_sort | higher triglyceride glucose index and triglyceride glucose body mass index protect against sarcopenia in chinese middle aged and older non diabetic women a cross sectional study |
| topic | sarcopenia triglyceride-glucose index triglyceride glucose-body mass index insulin resistance middle-aged and older non-diabetic women |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1475330/full |
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