Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses

Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses

Summary: Interleukin-10 (IL-10)-producing group 2 innate lymphoid cells (ILC210) regulate inflammatory immune responses, yet their therapeutic potential remains largely unexplored. Here, we demonstrate that cell therapy with human ILC210 inhibits pathogenic T cell responses in humanized mouse models...

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Bibliographic Details
Main Authors: Kyle T. Reid, Sarah J. Colpitts, Jessica A. Mathews, Abel Santos Carreira, Julia M. Murphy, Dorota T. Borovsky, Sinthuja Jegatheeswaran, Wenhui Cui, Tommy Alfaro Moya, Nadia Sachewsky, James An, Yubing Xia, Arthur Mortha, Jong Bok Lee, Li Zhang, Igor Novitzky-Basso, Jonas Mattsson, Sarah Q. Crome
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724014530
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