A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy

Abstract Mitochondrial diseases are a heterogeneous group of monogenic disorders that result from impaired oxidative phosphorylation (OXPHOS). As neuromuscular tissues are highly energy‐dependent, mitochondrial diseases often affect skeletal muscle. Although genetic and bioenergetic causes of OXPHOS...

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Main Authors: Nneka Southwell, Guido Primiano, Viraj Nadkarni, Nabeel Attarwala, Emelie Beattie, Dawson Miller, Sumaitaah Alam, Irene Liparulo, Yevgeniya I Shurubor, Maria Lucia Valentino, Valerio Carelli, Serenella Servidei, Steven S Gross, Giovanni Manfredi, Qiuying Chen, Marilena D'Aurelio
Format: Article
Language:English
Published: Springer Nature 2023-05-01
Series:EMBO Molecular Medicine
Subjects:
amino acid metabolism
glucocorticoids
leptin
mitochondrial myopathy
muscle wasting
Online Access:https://doi.org/10.15252/emmm.202216951
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https://doi.org/10.15252/emmm.202216951

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