Xanthosine alleviates myocardial ischemia–reperfusion injury through attenuation of cardiomyocyte ferroptosis

Xanthosine alleviates myocardial ischemia–reperfusion injury through attenuation of cardiomyocyte ferroptosis

Abstract Background Ischemic heart disease remains a leading cause of morbidity and mortality worldwide, with myocardial ischemia–reperfusion (I/R) injury significantly contributing to cardiomyocyte death and poor outcomes post-acute myocardial infarction (AMI). Emerging evidence highlights metaboli...

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Main Authors: Yang Xu, Wenfeng Zhou, Zhongguo Fan, Yiwei Cheng, Yujia Xiao, Yu Liu, Xinxin Li, Zhenjun Ji, Yi Fan, Genshan Ma
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cellular & Molecular Biology Letters
Subjects:
Xanthosine (XTS)
Ischemia–reperfusion (I/R) Injury
Ferroptosis
Purine metabolism
Reactive oxygen species (ROS)
Online Access:https://doi.org/10.1186/s11658-025-00766-y
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https://doi.org/10.1186/s11658-025-00766-y

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