Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer

Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer

Summary: Antibody–drug conjugates (ADCs) have become an important class of anticancer drugs in solid tumors including drug-resistant gynecologic malignancies. TROP2 is a cell surface antigen that is highly expressed in ovarian carcinoma (OC) but minimally expressed in normal ovarian tissues. In this...

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Bibliographic Details
Main Authors: Jayakumar R. Nair, Tzu-Ting Huang, Anu Sunkara, Margaret R. Pruitt, Kristen R. Ibanez, Chih-Yuan Chiang, Ken Chih-Chien Cheng, Kelli Wilson, Thomas M. Cardillo, Scott Hofsess, Jung-Min Lee
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Cancer
Molecular biology
Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224025082
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http://www.sciencedirect.com/science/article/pii/S2589004224025082

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