SIRT5-modified human umbilical cord mesenchymal stem cells loaded with antioxidant polydopamine nanozyme enhance parpi resistance in ovarian cancer via fatty acid metabolism reprogramming

SIRT5-modified human umbilical cord mesenchymal stem cells loaded with antioxidant polydopamine nanozyme enhance parpi resistance in ovarian cancer via fatty acid metabolism reprogramming

Abstract Ovarian cancer remains one of the most aggressive cancers, and resistance to Poly (ADP-ribose) Polymerase inhibitors (PARPi) poses a major therapeutic challenge. SIRT5, a NAD + -dependent desuccinylase, plays a crucial role in regulating fatty acid metabolism, which is often reprogrammed in...

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Bibliographic Details
Main Authors: Jin Zhang, Xiuluan Du, Xin Dai, Yanxiang Liu, Kai Guo, Donghua Gu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Antioxidant nanozyme-engineered stem cells
Multi-omics
Ovarian cancer
Poly (ADP-ribose) polymerase inhibitors resistance
SIRT5
Enoyl-CoA hydratase
Online Access:https://doi.org/10.1186/s12951-025-03516-6
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