Dengue infection changes the expressions of CD154 and CD148 in human platelets
Platelets are essential for hemostasis and vascular integrity. Platelets recognize dengue virus through the DC-SIGN receptor. Upon pathogen recognition, platelets rapidly modulate the expression of adhesion molecules to trigger immune cell interactions and regulate the immune response. In this study...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Virus Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168170224002120 |
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| author | Sayali Vedpathak Sonali Palkar AkhileshChandra Mishra Vidya A Arankalle Shubham Shrivastava |
| author_facet | Sayali Vedpathak Sonali Palkar AkhileshChandra Mishra Vidya A Arankalle Shubham Shrivastava |
| author_sort | Sayali Vedpathak |
| collection | DOAJ |
| description | Platelets are essential for hemostasis and vascular integrity. Platelets recognize dengue virus through the DC-SIGN receptor. Upon pathogen recognition, platelets rapidly modulate the expression of adhesion molecules to trigger immune cell interactions and regulate the immune response. In this study, we aimed to examine the expression levels of three molecules, CD151, CD154, and CD148 on platelets in dengue patients. A significantly increased expression of CD154 and reduced expression of CD148 was observed in dengue patients compared to healthy subjects (p < 0.0001). Moreover, a strong positive correlation between CD148 and CD41/CD61 (p < 0.0001) was noted in dengue patients. In summary, we demonstrated the altered expressions of CD154 and CD148 on platelets in dengue patients that may play a crucial role in dengue pathogenesis. |
| format | Article |
| id | doaj-art-3a50d619d5364e9e8941d80e8f7d71d2 |
| institution | Kabale University |
| issn | 1872-7492 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Virus Research |
| spelling | doaj-art-3a50d619d5364e9e8941d80e8f7d71d22025-01-09T06:12:16ZengElsevierVirus Research1872-74922025-01-01351199519Dengue infection changes the expressions of CD154 and CD148 in human plateletsSayali Vedpathak0Sonali Palkar1AkhileshChandra Mishra2Vidya A Arankalle3Shubham Shrivastava4Department of Translational Virology, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Katraj-Dhankawadi, Pune 411043, IndiaDepartment of Community Medicine, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Katraj-Dhankawadi, Pune 411043, IndiaDepartment of Translational Virology, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Katraj-Dhankawadi, Pune 411043, IndiaDepartment of Translational Virology, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Katraj-Dhankawadi, Pune 411043, IndiaDepartment of Translational Virology, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Katraj-Dhankawadi, Pune 411043, India; Corresponding author.Platelets are essential for hemostasis and vascular integrity. Platelets recognize dengue virus through the DC-SIGN receptor. Upon pathogen recognition, platelets rapidly modulate the expression of adhesion molecules to trigger immune cell interactions and regulate the immune response. In this study, we aimed to examine the expression levels of three molecules, CD151, CD154, and CD148 on platelets in dengue patients. A significantly increased expression of CD154 and reduced expression of CD148 was observed in dengue patients compared to healthy subjects (p < 0.0001). Moreover, a strong positive correlation between CD148 and CD41/CD61 (p < 0.0001) was noted in dengue patients. In summary, we demonstrated the altered expressions of CD154 and CD148 on platelets in dengue patients that may play a crucial role in dengue pathogenesis.http://www.sciencedirect.com/science/article/pii/S0168170224002120Dengue infectionPlateletsCD154CD148CD41/CD61 |
| spellingShingle | Sayali Vedpathak Sonali Palkar AkhileshChandra Mishra Vidya A Arankalle Shubham Shrivastava Dengue infection changes the expressions of CD154 and CD148 in human platelets Virus Research Dengue infection Platelets CD154 CD148 CD41/CD61 |
| title | Dengue infection changes the expressions of CD154 and CD148 in human platelets |
| title_full | Dengue infection changes the expressions of CD154 and CD148 in human platelets |
| title_fullStr | Dengue infection changes the expressions of CD154 and CD148 in human platelets |
| title_full_unstemmed | Dengue infection changes the expressions of CD154 and CD148 in human platelets |
| title_short | Dengue infection changes the expressions of CD154 and CD148 in human platelets |
| title_sort | dengue infection changes the expressions of cd154 and cd148 in human platelets |
| topic | Dengue infection Platelets CD154 CD148 CD41/CD61 |
| url | http://www.sciencedirect.com/science/article/pii/S0168170224002120 |
| work_keys_str_mv | AT sayalivedpathak dengueinfectionchangestheexpressionsofcd154andcd148inhumanplatelets AT sonalipalkar dengueinfectionchangestheexpressionsofcd154andcd148inhumanplatelets AT akhileshchandramishra dengueinfectionchangestheexpressionsofcd154andcd148inhumanplatelets AT vidyaaarankalle dengueinfectionchangestheexpressionsofcd154andcd148inhumanplatelets AT shubhamshrivastava dengueinfectionchangestheexpressionsofcd154andcd148inhumanplatelets |