Ergosterol Protects Canine MDCK Cells from Gentamicin-Induced Damage by Modulating Autophagy and Apoptosis

Ergosterol Protects Canine MDCK Cells from Gentamicin-Induced Damage by Modulating Autophagy and Apoptosis

<b>Background:</b> Renal injury is a critical health issue in pet dogs, often exacerbated by drug-induced nephrotoxicity such as gentamicin (GM). This study investigated the protective effects of ergosterol (Erg), a natural compound from edible mushrooms, against GM-induced damage in Mad...

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Bibliographic Details
Main Authors: Zhipeng Qin, Liuwei Xie, Yao Wang, Na Zhang, Hailong Bi, Mingqiang Song, Chao Xu
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Metabolites
Subjects:
ergosterol
gentamicin
MDCK cells
autophagy
apoptosis
oxidative stress
Online Access:https://www.mdpi.com/2218-1989/15/6/373
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