TRP channels in hepatocellular carcinoma: integrative Mendelian randomization and multi-omics analyses highlight MCOLN3/TRPV4 as candidate dual-effect biomarkers

TRP channels in hepatocellular carcinoma: integrative Mendelian randomization and multi-omics analyses highlight MCOLN3/TRPV4 as candidate dual-effect biomarkers

Abstract Background The causal relationship between Transient receptor potential (TRP) and hepatocellular carcinoma (HCC) remains unclear. Our study aimed to identify potential drug targets for HCC within the TRP family using Mendelian randomization (MR). Methods The gene expression quantitative tra...

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Bibliographic Details
Main Authors: Zhe Xu, Chong Pang, Xundi Xu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Human Genomics
Subjects:
Transient receptor potential
MCOLN3
TRPV4
Hepatocellular carcinoma
Mendelian Randomization
Drug target
Online Access:https://doi.org/10.1186/s40246-025-00807-9
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https://doi.org/10.1186/s40246-025-00807-9

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