Bioaugmented design and functional evaluation of low damage implantable array electrodes
Implantable neural electrodes are key components of brain-computer interfaces (BCI), but the mismatch in mechanical and biological properties between electrode materials and brain tissue can lead to foreign body reactions and glial scarring, and subsequently compromise the long-term stability of ele...
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KeAi Communications Co., Ltd.
2025-05-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X2400570X |
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| author | Ling Wang Chenrui Zhang Zhiyan Hao Siqi Yao Luge Bai Joaquim Miguel Oliveira Pan Wang Kun Zhang Chen Zhang Jiankang He Rui L. Reis Dichen Li |
| author_facet | Ling Wang Chenrui Zhang Zhiyan Hao Siqi Yao Luge Bai Joaquim Miguel Oliveira Pan Wang Kun Zhang Chen Zhang Jiankang He Rui L. Reis Dichen Li |
| author_sort | Ling Wang |
| collection | DOAJ |
| description | Implantable neural electrodes are key components of brain-computer interfaces (BCI), but the mismatch in mechanical and biological properties between electrode materials and brain tissue can lead to foreign body reactions and glial scarring, and subsequently compromise the long-term stability of electrical signal transmission. In this study, we proposed a new concept for the design and bioaugmentation of implantable electrodes (bio-array electrodes) featuring a heterogeneous gradient structure. Different composite polyaniline-gelatin-alginate based conductive hydrogel formulations were developed for electrode surface coating. In addition, the design, materials, and performance of the developed electrode was optimized through a combination of numerical simulations and physio-chemical characterizations. The long-term biological performance of the bio-array electrodes were investigated in vivo using a C57 mouse model. It was found that compared to metal array electrodes, the surface charge of the bio-array electrodes increased by 1.74 times, and the impedance at 1 kHz decreased by 63.17 %, with a doubling of the average capacitance. Long-term animal experiments showed that the bio-array electrodes could consistently record 2.5 times more signals than those of the metal array electrodes, and the signal-to-noise ratio based on action potentials was 2.1 times higher. The study investigated the mechanisms of suppressing the scarring effect by the bioaugmented design, revealing reduces brain damage as a result of the interface biocompatibility between the bio-array electrodes and brain tissue, and confirmed the long-term in vivo stability of the bio-array electrodes. |
| format | Article |
| id | doaj-art-39b3bd9da5c847d38c05ff9f48705934 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-39b3bd9da5c847d38c05ff9f487059342025-01-09T06:14:22ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-05-01471831Bioaugmented design and functional evaluation of low damage implantable array electrodesLing Wang0Chenrui Zhang1Zhiyan Hao2Siqi Yao3Luge Bai4Joaquim Miguel Oliveira5Pan Wang6Kun Zhang7Chen Zhang8Jiankang He9Rui L. Reis10Dichen Li11State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China; State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, China; Corresponding author. State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China.State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China; State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China; State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, China; Department of Intelligent Manufacture, Yantai Vocational College, 264670, ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China; State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China; State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, China3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Barco, 4805-017, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, PortugalDepartment of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, The Fourth Military 9 Medical University, 710032, Xi'an, ChinaDepartment of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, ChinaTianjin Medical Devices Quality Supervision and Testing Center, Tianjin, 300384, ChinaState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China; State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, China3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Barco, 4805-017, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, PortugalState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China; State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, China; Corresponding author. State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China.Implantable neural electrodes are key components of brain-computer interfaces (BCI), but the mismatch in mechanical and biological properties between electrode materials and brain tissue can lead to foreign body reactions and glial scarring, and subsequently compromise the long-term stability of electrical signal transmission. In this study, we proposed a new concept for the design and bioaugmentation of implantable electrodes (bio-array electrodes) featuring a heterogeneous gradient structure. Different composite polyaniline-gelatin-alginate based conductive hydrogel formulations were developed for electrode surface coating. In addition, the design, materials, and performance of the developed electrode was optimized through a combination of numerical simulations and physio-chemical characterizations. The long-term biological performance of the bio-array electrodes were investigated in vivo using a C57 mouse model. It was found that compared to metal array electrodes, the surface charge of the bio-array electrodes increased by 1.74 times, and the impedance at 1 kHz decreased by 63.17 %, with a doubling of the average capacitance. Long-term animal experiments showed that the bio-array electrodes could consistently record 2.5 times more signals than those of the metal array electrodes, and the signal-to-noise ratio based on action potentials was 2.1 times higher. The study investigated the mechanisms of suppressing the scarring effect by the bioaugmented design, revealing reduces brain damage as a result of the interface biocompatibility between the bio-array electrodes and brain tissue, and confirmed the long-term in vivo stability of the bio-array electrodes.http://www.sciencedirect.com/science/article/pii/S2452199X2400570XImplantable neural electrodesBioaugmented designBiocompatibilityScar tissue suppressionSignal-to-noise ratio |
| spellingShingle | Ling Wang Chenrui Zhang Zhiyan Hao Siqi Yao Luge Bai Joaquim Miguel Oliveira Pan Wang Kun Zhang Chen Zhang Jiankang He Rui L. Reis Dichen Li Bioaugmented design and functional evaluation of low damage implantable array electrodes Bioactive Materials Implantable neural electrodes Bioaugmented design Biocompatibility Scar tissue suppression Signal-to-noise ratio |
| title | Bioaugmented design and functional evaluation of low damage implantable array electrodes |
| title_full | Bioaugmented design and functional evaluation of low damage implantable array electrodes |
| title_fullStr | Bioaugmented design and functional evaluation of low damage implantable array electrodes |
| title_full_unstemmed | Bioaugmented design and functional evaluation of low damage implantable array electrodes |
| title_short | Bioaugmented design and functional evaluation of low damage implantable array electrodes |
| title_sort | bioaugmented design and functional evaluation of low damage implantable array electrodes |
| topic | Implantable neural electrodes Bioaugmented design Biocompatibility Scar tissue suppression Signal-to-noise ratio |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X2400570X |
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