The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein

Altered redox balance is among the main contributing factors developing glioblastoma multiforme (GBM), a highly aggressive grade IV brain tumor. Neuropeptide substance P (SP) plays a key role in modifying the cellular redox environment by activating the neurokinin-1 receptor (NK1R). In this study, w...

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Bibliographic Details
Main Authors: Negeen Mehrabani, Mohammad Reza Vaezi Kakhki, Hossein Javid, Safieh Ebrahimi, Seyed Isaac Hashemy
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Neurology Research International
Online Access:http://dx.doi.org/10.1155/2021/9966000
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