U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays

Abstract Untranslated RNA sequences play essential roles in orchestrating gene expression. However, the sequence codes and mechanisms underpinning post-transcriptional regulation remain incompletely understood. Here, we revisit the finding from a prior massively parallel reporter assay (MPRA) that A...

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Bibliographic Details
Main Authors: Khoa Dao, Courtney F. Jungers, Sergej Djuranovic, Anthony M. Mustoe
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62000-9
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