Esculetin inhibits ferroptosis after ICH by promoting NUDT1-mediated m7G methylation modification of GPX4

Esculetin inhibits ferroptosis after ICH by promoting NUDT1-mediated m7G methylation modification of GPX4

Abstract Intracerebral hemorrhage (ICH) is the most morbid of all stroke types with a high mortality and significant disability burden. Inhibiting ferroptosis after ICH will effectively treat ICH and improve prognosis. Esculetin is the main active ingredient of the Chinese medicine Cortex Fraxini, w...

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Bibliographic Details
Main Authors: Jinbing Gong, Zhanwei Zhang, Libo Li, Zhigang Mei, Tao Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Intracerebral hemorrhage
Esculetin
Ferroptosis
m7G methylation modification
NUDT1
GPX4
Online Access:https://doi.org/10.1038/s41598-025-16869-7
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https://doi.org/10.1038/s41598-025-16869-7

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