Cefiderocol Resistance Conferred by Plasmid-Located Ferric Citrate Transport System in KPC-Producing Klebsiella pneumoniae

Cefiderocol Resistance Conferred by Plasmid-Located Ferric Citrate Transport System in KPC-Producing Klebsiella pneumoniae

Cefiderocol (FDC), a siderophore-cephalosporin conjugate, is the newest option for treating infection with carbapenem-resistant gram-negative bacteria. We identified a novel mechanism contributing to decreased FDC susceptibility in Klebsiella pneumoniae clinical isolates. The mechanism involves 2 c...

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Bibliographic Details
Main Authors: Riccardo Polani, Alice De Francesco, Dario Tomolillo, Irene Artuso, Michele Equestre, Rita Trirocco, Gabriele Arcari, Guido Antonelli, Laura Villa, Gianni Prosseda, Paolo Visca, Alessandra Carattoli
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2025-01-01
Series:Emerging Infectious Diseases
Subjects:
Klebsiella pneumoniae
carbapenemase-producing Klebsiella pneumoniae
KPC
cefiderocol
antimicrobial resistance
siderophore
Online Access:https://wwwnc.cdc.gov/eid/article/31/1/24-1426_article
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https://wwwnc.cdc.gov/eid/article/31/1/24-1426_article

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