Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1G93A ALS mouse model

Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1G93A ALS mouse model

Abstract Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal paralytic disorder associated with motor neuron death. Mutant superoxide dismutase 1 (SOD1) misfolding and aggregation have been linked to familial ALS, with the accumulation of abnormal wild-type SOD1 species being also observ...

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Main Authors: Luis Labrador, Leonardo Rodriguez, Sebastián Beltran, Fernanda Hernandez, Laura Gomez, Patricia Ojeda, Cristian Bergmann, Melissa Calegaro-Nassif, Bredford Kerr, Danilo B. Medinas, Patricio Manque, Ute Woehlbier
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Biological Research
Subjects:
PACER
RUBCNL
KIAA0226L
Autophagy
Amyotrophic lateral sclerosis
Superoxide dismutase 1
Online Access:https://doi.org/10.1186/s40659-024-00567-1
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https://doi.org/10.1186/s40659-024-00567-1

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