A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability

A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability

Abstract Peripheral T‐cell lymphoma (PTCL) represents a rare group of heterogeneous diseases in urgent need of effective treatments. A scarcity of disease‐relevant preclinical models hinders research advances. Here, we isolated a novel mouse (m)PTCL by serially transplanting a lymphoma from a germin...

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Main Authors: Elizabeth A Kuczynski, Giulia Morlino, Alison Peter, Anna M L Coenen‐Stass, Jennifer I Moss, Neha Wali, Oona Delpuech, Avinash Reddy, Anisha Solanki, Charles Sinclair, Dinis P Calado, Larissa S Carnevalli
Format: Article
Language:English
Published: Springer Nature 2022-05-01
Series:EMBO Molecular Medicine
Subjects:
DNA damage response
GATA3
peripheral T‐cell lymphoma
syngeneic mouse model
T‐follicular helper cell
Online Access:https://doi.org/10.15252/emmm.202215816
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https://doi.org/10.15252/emmm.202215816

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