Association of LVV-Hemorphin-7 with Sepsis and Shock: Roles of Cathepsin D and G in Hemoglobin Metabolism in a Prospective ICU Cohort Study

Association of LVV-Hemorphin-7 with Sepsis and Shock: Roles of Cathepsin D and G in Hemoglobin Metabolism in a Prospective ICU Cohort Study

Background: Sepsis is a leading cause of mortality in intensive care units (ICUs). Cell-free hemoglobin (CFH) released during sepsis interacts with lysosomal enzymes from neutrophils and macrophages. This study aims to examine the association of LVV-hemorphin-7 (LVV-H7), cathepsin D, and cathepsin G...

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Main Authors: Yao-Kuang Wu, Hsueh-Wen Chung, Yi-Ting Chen, Hsing-Chun Chen, I-Hung Chen, Wen-Lin Su
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomedicines
Subjects:
sepsis
shock
cathepsin
LVV-hemorphin-7
sequential organ failure assessment score
Online Access:https://www.mdpi.com/2227-9059/12/12/2789
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