Structural basis of voltage-dependent gating in BK channels

Abstract The allosteric communication between the pore domain, voltage sensors, and Ca2+ binding sites in the calcium- and voltage-activated K+ channel (BK) underlies its physiological role as the preeminent signal integrator in excitable systems. BK displays shallow voltage sensitivity with very fa...

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Bibliographic Details
Main Authors: Gustavo F. Contreras, Rong Shen, Ramon Latorre, Eduardo Perozo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60639-y
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