Curcumin-based polymer prodrug nanoplatform for high-efficiency immunotherapy by synergistically suppression of head and neck cancer cell stemness

Curcumin-based polymer prodrug nanoplatform for high-efficiency immunotherapy by synergistically suppression of head and neck cancer cell stemness

Abstract Background Immunotherapy represents a transformative advance in cancer treatment; however, its efficacy in head and neck cancer (HNC) remains constrained by tumor cell stemness and profound immunosuppression within the tumor microenvironment (TME). Overcoming these barriers necessitates inn...

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Bibliographic Details
Main Authors: Zhisen Shen, Hao Jiang, Shuaijun Lu, Hailong Tian, Feng Gao, Hongxia Deng, Canhua Huang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Head and neck cancer
Curcumin-based nanoplatform
Immunotherapy
Tumor cell stemness
Immunogenic cell death (ICD)
Online Access:https://doi.org/10.1186/s12951-025-03559-9
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https://doi.org/10.1186/s12951-025-03559-9

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