A Simplified Method for Evaluating Chitin-Binding Activity Applied to YKL-40 (HC-gp39, CHI3L1) and Chitotriosidase

A Simplified Method for Evaluating Chitin-Binding Activity Applied to YKL-40 (HC-gp39, CHI3L1) and Chitotriosidase

YKL-40 is structurally similar to chitotriosidase (CHIT1), an active chitinase, but it lacks chitin-degrading activity while retaining chitin-binding capability. Elevated YKL-40 levels are associated with inflammatory diseases and cancers, making it a valuable biomarker. We previously reported that...

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Bibliographic Details
Main Authors: Keita Suzuki, Hidetoshi Suzuki, Ami Tanaka, Miwa Tanaka, Kairi Takase, Hiromu Takei, Tomoki Kanaizumi, Kazuaki Okawa, Peter O. Bauer, Fumitaka Oyama
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
catalytic domain (CatD)
chitin
chitin-binding activity
chitin-binding affinity assay
chitin-binding domain (CBD)
chitotriosidase (CHIT1)
Online Access:https://www.mdpi.com/1420-3049/30/1/19
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