Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection

Gammaherpesviruses are oncogenic pathogens that establish lifelong infections. There are no FDA-approved vaccines against Epstein–Barr virus or Kaposi sarcoma herpesvirus. Murine gammaherpesvirus-68 (MHV68) infection of mice provides a system for investigating gammaherpesvirus pathogenesis and testi...

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Bibliographic Details
Main Authors: Dipanwita Mitra, Darby G. Oldenburg, J. Craig Forrest, Laurie T. Krug
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Viruses
Subjects:
gammaherpesvirus
MHV68
vaccine
replication-dead virus
latency establishment
reactivation
Online Access:https://www.mdpi.com/1999-4915/16/12/1930
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https://www.mdpi.com/1999-4915/16/12/1930

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