A nucleoside-modified mRNA vaccine prevents enterovirus A71 infection in mouse model

A nucleoside-modified mRNA vaccine prevents enterovirus A71 infection in mouse model

IntroductionHuman Enterovirus A71 (EV-A71) is the primary pathogen responsible for severe hand, foot, and mouth disease (HFMD). Vaccination plays a crucial role in controlling its spread. Although inactivated vaccines have been approved, there is growing interest in developing new candidates using a...

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Main Authors: Fengyu Chi, Xu Zhang, Dong Zhang, Airu Zhu, Zhen Zhuang, Zhaoyong Zhang, Zhenjie Zhang, Chuansong Quan, Kaixiao Nie, Juan Li, Chunhong Yin, Jie Tong, Yuming Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
human enterovirus A71
non-enveloped virus
VP1
mRNA vaccine
immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535758/full
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